Furosemide CAS 54-31-9 API Active Pharmaceutical Ingredient

Product Description:

Product Name: Furosemide CAS NO: 54-31-9

Synonyms:

2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid

4-Chloro-N-Furfuryl-5-Sulfamoylanthranilic Acid;

Furosemide,5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoicacid;

Chemical & Physical Properties:

Appearance: White powder

Assay :≥99%

Density: 1.606

Boiling Point: 582.1℃ at 760 mmHg

Melting Point: 220℃

Flash Point: 305.9℃

Storage Condition: 2-8℃

Water Solubility: Soluble in aceto-ne, DMF or methanol. Slightly soluble in water

Stability: Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents.

Safety Information:

RTECS: CB2625000

RIDADR: UN 1230 3/PG 2

Risk Statement: R61

WGK Germany: 3

Hazard Codes: T,F,Xi

Hazard Statement: H360

HS Code: 2942000000

Symbol: GHS08

Signal Word: Danger

Safety Statements: S22-S36/37/39-S53-S45

Precautionary Statements: P201-P308 + P313

Furosemide, sold under the brand name Lasix among others, is a medication used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It may also be used for the treatment of high blood pressure. The amount of medication required depends on the person in question. It can be taken intravenously or by mouth. When taken by mouth it typically begins working within an hour while intravenously it typically begins working within five minutes.

Common side effects include low blood pressure with standing, ringing in the ears, and sensitivity to the sun. Potentially serious side effects include electrolyte abnormalities, low blood pressure, and hearing loss. Blood tests are recommended regularly for those on treatment. Furosemide is a type of loop diuretic that works by decreasing the reabsorption of sodium by the kidneys.

Furosemide was discovered in 1962. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. The wholesale price in the developing world is between 0.004 and 0.02 USD per day. In the United States it is available as a generic medication and costs about 0.15 USD per day. Furosemide is on the World Anti-Doping Agency's banned drug list due to concerns that it may mask other drugs. It has also been used to prevent and treat race horses for exercise-induced pulmonary hemorrhage.

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