Nystatin CAS 1400-61-9 API Active Pharmaceutical Ingredient

Product Description:

Product Name: Nystatin CAS NO: 1400-61-9

Synonyms:

Nystatin Suspension;

Fungicidin, Mycostatin;

20-(4-Amino-3,5-dihydroxy-6-methyl-oxan-2-yl)oxy-4,22,24,28,29,32,34,36-octahydroxy-2,3,5-trimethyl-26,38-dioxo-1-oxacyclooctatriaconta-6,8,12,14,16,18-hexaene-23-carboxylic acid;

Chemical & Physical Properties:

Appearance: Yellow suspension

Assay :≥99%

Boiling Point: 476℃ at 760mmHg

Flash Point: 127.3℃

Refractive Index: 1.503

Storage Condition: -20℃

Vapor Pressure: 1.6E-07mmHg at 25℃

Odor: Suggestive of cereals odor

Water Solubility: 0.36g/L(24℃)

Solubility: H2O: insoluble

Safety Information:

Hazard Codes: F; C

HS Code: 2942000000

WGK Germany: 3

Risk Statement: R11-34

RTECS: RF5950000

Safety Statements: S22-S24/25

Toxicity: LD50 i.p. in mice: ~200 mg/kg (Seneca)

Nystatin, sold under the brandname Mycostatin among others, is an antifungal medication. It is used to treat Candida infections of the skin including diaper rash, thrush, esophageal candidiasis, and vagin-al yeast infections. It may also be used to prevent candidiasis in those who are at high risk. Nystatin may be used by mouth, in the vagi-na, or applied to the skin.

Nystatin was discovered in 1950 by Rachel Fuller Brown and Elizabeth Lee Hazen. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale price of the cream in the developing world is about 0.70 USD per 30 gram tube. In the United States it is less than 25 USD for a course of treatment. It is made from the bacterium, Streptomyces noursei.

Nystatin is polyene antifungal containing a conjugated tetraene and a diene, isolated as a complex of three components A1, A2 and A3 from Streptomyces noursei and first reported in 1950. Nystatin, like most polyene antifungals, binds to sterols in the fungal cell membrane leading to formation of ion channels in the wall, ion imbalance and cell death. Nystatin is an established bioprobe and widely-used antifungal reagent with over 4,000 literature citations.

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