Pramipexole Dihydrochloride CAS 104632-25-9

Product Description:

Product Name: Pramipexole dihydrochloride CAS NO: 104632-25-9

Synonyms:

PramipexoleDihcl;

(s)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride;

(s)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine, Dihydrochloride;

Chemical & Physical Properties:

Appearance: White crystalline powder

Assay :≥99%

Boiling Point: 378℃ at 760 mmHg

Melting Point: 288-290℃

Flash Point: 182.4℃

Vapor Pressure: 6.49E-06mmHg at 25℃

Storage Temp. : Desiccate at RT

Solubility: H2O: >20mg/Ml

Safety Information:

HS Code: 2934999090

WGK Germany: 3

Mirapex, and non-ergot derivative, was launched in the US for treatment of Parkinson's disease. It can be prepared by two related routes, 5 steps and 3 steps, both involving an optical resolution with L-(+)-tartaric acid to afford the (S)-isomer. Mechanistically, it is a presynaptic dopamine D2 autoreceptor agonist which also activates D3-receptors. It is well absorbed from the GI and excreted in the urine essentially unchanged with a half-life of 8-12 hr. Mirapex had favorable effects on the symptoms without levodopa for patients with advanced PD and allowed a 27% reduction in use of levodopa in combination therapy. It had an adverse events profile similar to other dopamine agonists and in advanced patients reduced the mean "on-off" hr/day from 6 to 4. It was safe but not efficacious in all patients.A dopamine-D2-receptor agonist. Antiparkinsonian.

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