Dansyl Chloride CAS 605-65-2 API Active Pharmaceutical Ingredient

Product Description:

Product Name: dansyl chloride CAS NO: 605-65-2

Synonyms:

1-Naphthalenesulfonyl chloride, 5-(dimethylamino)-;

1-chlorosulfonyl-5-dimethylaminonaphthalene;

5-(dimethylamino)naphthalene-1-sulfonyl chloride;

Chemical & Physical Properties:

Appearance: Yellow fine crystalline powder

Assay :≥99%

Density: 1.361 g/cm3

Boiling Point: 371.3℃ at 760 mmHg

Melting Point: 70-73℃

Flash Point: 178.4℃

Refractive Index: 1.636

Storage Condition: 2-8℃

Stability: Stable under normal temperatures and pressures

Safety Information:

Symbol: GHS05

Signal Word: Danger

RTECS: QK3688000

Hazard Class: 8

Hazard Code: C

HS Code: 29214980

Packing Group: III

WGK Germany: 3

RIDADR: UN 3261

Risk Statement: R34

Hazard Declaration: H314

Safety Statements: S26-S36/37/39-S45

Caution Statements: P280; P305 + P351 + P338; P310

Dansyl chloride or 5-(DimethylAmino)Naphthalene-1-SulfonYL chloride is a reagent that reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green–fluorescent sulfonamide adducts. It can also be made to react with secondary amines. Dansyl chloride is widely used to modify amino acids; specifically, protein sequencing and amino acid analysis. It can also be used to label hydroxyl and carboxylic acid functional groups.

Dansyl chloride may also be denoted DNSC. Likewise, a similar derivative, dansyl amide is known as DNSA. Besides, these protein-DNSC conjugates are sensitive to their immediate environment. This, in combination with their ability to accept energy (as in fluorescence resonance energy transfer) from the amino acid tryptophan, allows this labeling technique to be used in investigating protein folding and dynamics.

The fluorescence of these sulfonamide adducts can be enhanced by adding alpha-cyclodextrin. Dansyl chloride is unstable in dimethyl sulfoxide, which should never be used to prepare solutions of the reagent.The extinction coefficient of dansyl derivatives are important for measuring their concentration in solution. Dansyl chloride is one of the simplest sulfonamide derivatives, so it commonly serves as a starting reagent for the production of other derivatives. Exotic derivatives may have very different extinction coefficients, but others, such as dansyl amide, are similar to dansyl chloride in absorption and fluorescence characteristics. But even for dansyl chloride, there are a variety of extinction coefficient values that have been reported. Some of the values are used to estimate the extent of success in attempts to conjugate the dye to a protein. Other values may be used to determine a precise concentration of a stock solution. See the table below for specific values and their uses.

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