2-(3-aminopropylamino)ethylsulfanylphosphonic Acid,trihydrate CAS 112901-68-5

Product Description:

Product Name: 2-(3-aminopropylamino)ethylsulfanylphosphonic acid,trihydrate CAS NO: 112901-68-5

Synonyms:

Amifostine (150 mg);

Anifostine trihydrate;

Ethanethiol,2-[(3-aMinopropyl)aMino]-, 1-(dihydrogen phosphate), hydrate (1:3);

Chemical & Physical Properties:

Appearance: Powder

Assay :≥99.0%

Density: 1.367g/cm3

Boiling Point: 441.7℃ at 760 mmHg

Flash Point: 220.9℃

Storage Temp.: 2-8℃

PKa: pKa1 <2.0; pKa2 4.2; pKa3 9.0; pKa4 11.7(at 25℃)

Vapor Pressure: 4.9E-09mmHg at 25℃

Safety Information:

Symbol: GHS07

Signal Word: Warning

Risk Statement: R22

Safety Statements: S26-36

WGK Germany: 3

RTECS: TE6491000

Hazard Code: Xn

HS Code: 2930909165

Hazard Statement: H302

Precautionary Statements: P301 + P312 + P330

Amifostine is a broad-spectrum cell protectant. It was once used as a military anti-radiation agent, and is now used as a protective drug for radiotherapy and chemotherapy. It was effective in reducing the side effects of anti-cancer drugs such as cyclophosphamide, chloroplatin, doxorubicin and anti-HIV drugs such as 3-azido-3-deoxythymidine, and Chemicalbook did not affect the efficacy of anti-cancer drugs or anti-HIV drugs. Amifotin is currently available as a freeze-dried powder injection from Life Sciences Inc., under the trade name Ethyol. The product is available only as a lyophilized powder injection, but the amorphous form produced by the low pressure lyophilized process is heat unstable. Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action.

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