Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1698055-85-4
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1698055-85-4 |
Appearance:: |
Off-white To White Solid |
Molecular Formula:: |
C21H17ClF2N4O2 |
Molecular Weight:: |
430.83500 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
CAS NO:: |
1698055-85-4 |
Appearance:: |
Off-white To White Solid |
Molecular Formula:: |
C21H17ClF2N4O2 |
Molecular Weight:: |
430.83500 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
Product Description:
Product Name: ARS-1620 CAS NO: 1698055-85-4
Synonyms:
(R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one;
2-Propen-1-one,1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-;
Chemical & Physical Properties:
Appearance: Off-white to white solid
Assay :≥98.0%
Boiling Point: 614.7±55.0℃(Predicted)
Density: 1.434±0.06 g/cm3 (Predicted)
PKa: 6.03±0.35 (Predicted)
ARS-1620 is a potent and orally active covalent inhibitor of KrasG12c, which produces rapid and sustained binding (seizure) of targets in vivo and induces tumor regression. ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics. ARS-1620 is a potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor. ARS-1620 inhibits KRAS with high potency in cells and animals. Moreover, ARS-1620 achieves rapid and sustained in vivo target occupancy to induce tumor regression.
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