Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1369489-71-3
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1369489-71-3 |
Appearance:: |
Solid Or Powder |
Molecular Formula:: |
C22H18F5N3O4 |
Molecular Weight:: |
483.38800 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
CAS NO:: |
1369489-71-3 |
Appearance:: |
Solid Or Powder |
Molecular Formula:: |
C22H18F5N3O4 |
Molecular Weight:: |
483.38800 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
Product Description:
Product Name: ER-886046-00 CAS NO: 1369489-71-3
Synonyms:
(S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid;
E7046;
Benzoicacid,4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-;
Chemical & Physical Properties:
Appearance: Solid or powder
Assay :≥99.0%
Density: 1.43±0.1 g/cm3(Predicted)
Boiling Point: 594.8±50.0℃(Predicted)
Flash Point: 313.5±30.1℃
PKa: 4.17±0.10 (Predicted)
Vapor Pressure: 0.0±1.8 mmHg at 25℃
Index of Refraction: 1.564
E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities. E-7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4 (IC₅₀ = 13.5 nM). It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.
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