Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1434635-54-7
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1434635-54-7 |
Appearance:: |
White Solid |
Molecular Formula:: |
C28H31N3O8S |
Molecular Weight:: |
569.62600 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
CAS NO:: |
1434635-54-7 |
Appearance:: |
White Solid |
Molecular Formula:: |
C28H31N3O8S |
Molecular Weight:: |
569.62600 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
Product Description:
Product Name: ND-630 CAS NO: 1434635-54-7
Synonyms:
(R)-2-(1-(2-(2-methoxyphen-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid;
ND-630;
EOS-61252;
Chemical & Physical Properties:
Appearance: White solid
Assay :≥99.0%
Density: 1.42±0.1 g/cm3 (Predicted)
Boiling Point: 779.0±70.0℃ (Predicted)
Flash Point: 424.9±35.7℃
PKa: 3.66±0.10 (Predicted)
Vapor Pressure: 0.0±2.8 mmHg at 25℃
Index of Refraction: 1.645
Storage Condition: -20℃
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively. ND-630 is potent, and reversible acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC₅₀ values of 2.1 and 6.1 nM, respectively. When administered chronically to Zucker diabetic fatty rats, ND-630 reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c (0.9% reduction).
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