Bardoxolone CAS 218600-44-3

Product Description:

Product Name: Bardoxolone CAS NO: 218600-44-3

Synonyms:

2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid;

2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid;

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid;

Chemical & Physical Properties:

Appearance: Tan solid

Assay :≥98.0%

Density: 1.18

Boiling Point: 632.9℃ at 760 mmHg

Melting Point: 180-182℃

Flash Point: 336.6℃

Refractive Index: 1.574

Vapor Pressure: 1.2E-17mmHg at 25℃

Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription fa ctor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.

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