Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1321514-06-0
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1321514-06-0 |
Appearance:: |
Solid Or Powder |
Molecular Formula:: |
C15H11ClFN5 |
Molecular Weight:: |
315.73300 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
CAS NO:: |
1321514-06-0 |
Appearance:: |
Solid Or Powder |
Molecular Formula:: |
C15H11ClFN5 |
Molecular Weight:: |
315.73300 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
Product Description:
Product Name: AZD-4635 CAS NO: 1321514-06-0
Synonyms:
HTL-1071;
1,2,4-Triazin-3-amine, 6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-;
6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine;
Chemical & Physical Properties:
Appearance: Solid or powder
Assay :≥99.0%
Boiling Point: 491.5±55.0℃(Predicted)
Density: 1.387±0.06 g/cm3 (Predicted)
PKa: 1.75±0.63 (Predicted)
Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that can bind to human A2AR with a Ki value of 1.7 nM, which is more than 30 times more selective for A2AR than other adenosine receptors. In CHO cells stably expressing human A2AR, AZD4625 inhibited cAMP production with IC50 values of 0.79, 10.0 and 142.9 nM in the presence of 0.1, 1 and 10 μmadenosine, respectively. Inhibition of A2AR by AZD4625 can reduce tumor load and enhance anti-tumor immunity.
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