BLU9931 CAS 1538604-68-0

Product Description:

Product Name: BLU9931 CAS NO: 1538604-68-0

Synonyms:

2-Propenamide,N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]-;

LM-3610;

Chemical & Physical Properties:

Appearance: Solid or powder

Assay :≥98.0%

Density: 1.361±0.06 g/cm3 (Predicted)

PKa: 13.15±0.70 (Predicted)

Index of Refraction: 1.677

BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with an IC50 of 3 nM and a selectivity of 297,184 and 50 times higher than that for FGFR1/2/3, respectively. In M-DA-MB-453 cells, BLU9931 effectively inhibited the phosphorylation of FGFR4 signaling pathway. Blu9931 inhibited the proliferation of HCC cell lines, such as Hep3B, Huh-7, Chemicalbook, and JHH-7, expressing an intact FGFR4 signaling complex with EC50<1 μm. BLU9931 also inhibits proliferation in PDX-derived cell lines with an intact FGFR4 signaling pathway. In mice loaded with FGF19-amplified Hep3B liver tumors, BLU9931(300mg/kg, P.O.) caused tumor degeneration and prevented tumor-induced weight loss. Blu9931 (300mg/kg, P.O.) treatment also resulted in tumor degeneration in Chemicalbook loaded mice with FGF19- overexpression of PDX-derived LIXC012 xenograft.

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.