Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1035270-39-3
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1035270-39-3 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C26H33N5O3 |
Molecular Weight:: |
463.57200 |
EINECS NO:: |
681-057-4 |
MDL NO:: |
MFCD22580423 |
CAS NO:: |
1035270-39-3 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C26H33N5O3 |
Molecular Weight:: |
463.57200 |
EINECS NO:: |
681-057-4 |
MDL NO:: |
MFCD22580423 |
Product Description:
Product Name: AZD-4547 CAS NO: 1035270-39-3
Synonyms:
N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide;
QCR-89;
Chemical & Physical Properties:
Appearance: Crystalline solid
Assay :≥98.0%
Density: 1.189
Boiling Point: 621.7±55.0℃ (Predicted)
PKa: 13.66±0.10 (Predicted)
Flash Point: 329.8±31.5℃
Vapor Pressure: 0.0±1.8 mmHg at 25℃
Index of Refraction: 1.602
AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine kinases and is under clinical investigation for the treatment of FGFR-dependent tumors. AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.
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