Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 929095-18-1
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
929095-18-1 |
Appearance:: |
White To Gray Solid |
Molecular Formula:: |
C27H28F3N5O2S |
Molecular Weight:: |
543.60400 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD12755419 |
CAS NO:: |
929095-18-1 |
Appearance:: |
White To Gray Solid |
Molecular Formula:: |
C27H28F3N5O2S |
Molecular Weight:: |
543.60400 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD12755419 |
Product Description:
Product Name: GSK-461364 CAS NO: 929095-18-1
Synonyms:
2-Thiophenecarboxamide,5-[6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-;
5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide;
Chemical & Physical Properties:
Appearance: White to gray solid
Assay :≥99.0%
Density: 1.39 g/cm3
Boiling Point: 658℃at 760 mmHg
Flash Point: 351.7℃
PKa: 15.16±0.50 (Predicted)
Vapor Pressure: 0.0±2.0 mmHg at 25℃
Index of Refraction: 1.645
GSK461364 inhibited purified PLK1 with Ki of 2 nM, which was 1000 times more selective than that used for PLK2/3. Phase 1. GSK461364 is a potent, reversible ATP-competitive PLK1 selective inhibitor that acts on PLK1 compared to at least 390 times more selective against PLK2 and PLK3 and 1×103 times more selective against a group of 48 other kinases.
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