Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1942114-09-1
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1942114-09-1 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C19H14FN3O3S |
Molecular Weight:: |
383.39600 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
CAS NO:: |
1942114-09-1 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C19H14FN3O3S |
Molecular Weight:: |
383.39600 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
Product Description:
Product Name: EAI045 CAS NO: 1942114-09-1
Synonyms:
2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-;
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide;
α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-2H-Isoindole-2-acetamide;
Chemical & Physical Properties:
Appearance: Crystalline solid
Assay :≥99.0%
Density: 1.546±0.06 g/cm3 (Predicted)
PKa: 7.20±0.50 (Predicted)
Index of Refraction: 1.729
EAI045 is a potent and selective EGFR inhibitor (fourth generation). EAI045 targets selected drug-resistant EGFR mutants without affecting the wild-type receptor. EAI045 inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays. Therefore, it is a potential candidate drug for the treatment of related non-small cell lung cancer (NSCLC). It should be noted that EAI-045 is effectively in targeting the EGFR C797S mutation, which is resistance to the third-generation EGFR inhibitors including AZD9291 (osimertinib) and CO-1686 (rociletinib).
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