Biphenyl-2-ylcarbamicacid1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-ylester CAS 864

Product Description:

Product Name:

biphenyl-2-ylcarbamicacid1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-ylester CAS NO: 864750-70-9

Synonyms:

1-(2-(3-((4-carbamoylpiperidin-1-yl)methyl)-N-methylbenzamido)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate;

Revefenacin:TD-4208:GSK-1160724;

TD-4208;

Chemical & Physical Properties:

Appearance: Crystalline solid

Assay :≥98.0%

Density: 1.26±0.1 g/cm3(Predicted)

Melting Point: 125℃

Boiling Point: 777.5±60.0℃(Predicted)

PKa: 13.34±0.70(Predicted)

Flash Point: 424.0±32.9℃

Vapor Pressure: 0.0±2.7 mmHg at 25℃

Index of Refraction: 1.645

Revefenacin is a novel structural, non-selective, long-acting muscarinic alkaline antagonist that blocks M3 receptors in respiratory smooth muscle. Blockage of these receptors prevents acetylcholine - induced bronchial constriction, thus resulting in bronchial relaxation. Common adverse reactions (1%-10%) in clinical trials were headache, nasopharyngitis, upper respiratory tract infection, back pain, bronchitis, dizziness, hypertension, etc.

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