AZD8186 CAS 1627494-13-6

Product Description:

Product Name: AZD8186 CAS NO: 1627494-13-6

Synonyms:

8-[(1R)-1-[(3,5-Difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-6-carboxamide;

(R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide;

Chemical & Physical Properties:

Appearance: Solid powder

Assay :≥98.0%

Density: 1.351±0.06 g/cm3 (Predicted)

Boiling Point: 645.2±55.0℃(Predicted)

PKa: 2.56±0.50 (Predicted)

Flash Point: 344.0±31.5℃

Vapor Pressure: 0.0±1.9 mmHg at 25℃

Index of Refraction: 1.618

AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials.

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