Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 950769-58-1
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
950769-58-1 |
Appearance:: |
White Powder |
Molecular Formula:: |
C29H32N6O4S |
Molecular Weight:: |
560.66700 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD18074524 |
CAS NO:: |
950769-58-1 |
Appearance:: |
White Powder |
Molecular Formula:: |
C29H32N6O4S |
Molecular Weight:: |
560.66700 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD18074524 |
Product Description:
Product Name: AC-220 CAS NO: 950769-58-1
Synonyms:
1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea;
N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea;
Chemical & Physical Properties:
Appearance: White powder
Assay :≥99.0%
Density: 1.39±0.1 g/cm3 (Predicted)
PKa: 12.59±0.70 (Predicted)
Index of Refraction: 1.691
Quizartinib (AC220) is a small molecule receptor tyrosine kinase inhibitor that is currently under development by Ambit Biosciences for the treatment of acute myeloid leukaemia. Its molecular target is FLT3, also known as CD135 which is a proto-oncogene.
Flt3 mutations are among the most common mutations in acute myeloid leukaemia due to internal tandem duplication of Flt3. The presence of this mutation is a marker of adverse outcome.
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