BAY-61-3606 CAS 648903-57-5

Product Description:

Product Name: BAY-61-3606 CAS NO: 648903-57-5

Synonyms:

2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide,dihydrochloride;

BAY 61-3606 dihydrochloride;

UNII-96PPV9GQ7A;

Chemical & Physical Properties:

Appearance: Yellow solid

Assay :≥98.0%

BAY-61-3606 is a potent, selective Syk kinase inhibitor with a Ki of 7.5 nM. BAY-61-3606 can induce cell cycle arrest and apoptosis. AY61-3606 is a highly specific inhibitor of Syk kinase. Other tyrosine kinases such as Lyn,Fyn,Src, ITK and BTK were not inhibited by BAY61-3606 at a concentration of 4.7μm. BAY61-3606 inhibits the signaling pathway mediated by B cell receptors. BAY61-3606 was also an sensitizer for TRAIL induced apoptosis. BAY61-3606 down-regulated MCL-1 in a dose-dependent and time-dependent manner in MCF-7 cells. BAY61-3606 reduces phosphorylation of SYK in McChemicalBookF-7 and T47D cells. In breast cancer cells, BAY61-3606 down-regulated MCL-1 independently of SYK. In MCF-7 cells. BAY61-3606 promoted the degradation of ubiquitin/proteasome dependent MCL-1 protein, and inhibited CDK9 phosphorylation, RNA polymerase Ⅱ and MCL-1 expression. In vitro, BAY61-3606 inhibited CDK9 kinase activity with an IC50 value of 37nM.

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.