Pyridine-3-aldehyde CAS 500-22-1

Product Description:

Product Name:Pyridine-3-aldehyde CAS 500-22-1

Synonyms:

Pyridinecarboxaldehyde;

Nicotinaldehyde;

Chemical & Physical Properties

Appearance:Clear brown - yellow liquid

Assay: 99%+

Boiling point:78-81℃10 mmHg

Melting point:8℃

Flash point:140℃

Pka:3.43±0.10

PH:5.4 (111g/l, H2O, 20℃)

Density:1.141 g/mL at 20℃³

Application

3-pyridine-formaldehyde is an intermediate of pyrazinone.3-methylpyridine reacts with glacial acetic acid and hydrogen peroxide, the reaction temperature is 63℃, the reaction time is 17h, the molar ratio of 3-methylpyridine, glacial acetic acid and hydrogen peroxide is 1:4:3.5, and 3-pyridine nitrogen oxide is obtained; 3-pyridine nitride oxide reacts with acetic anhydride, the reaction temperature is 92℃, the reaction time is 4h, the molar ratio of 3-pyridine nitride oxide and acetic anhydride is 1:2.3, and acetic acid - 3-pyridine methyl ester is obtained; acetic acid-3-pyridine methyl ester reacts with potassium hydroxide solution, the reaction time is 5h, the molar ratio of the acetic acid-3-pyridine methyl ester and potassium hydroxide is 1:1.8, the reaction obtains 3-pyridine methanol; 3-pyridinolinol is cooled by ice water and PCC is added. The molar ratio of the 3-pyridinolinol and PCC is 1:2.5 and the temperature is 2℃. It then reacts at room temperature, at 23 degrees Celsius, and is monitored by thin layer chromatography until the reaction is complete.

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