Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 41404-58-4
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Bag,Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS No:: |
41404-58-4 |
Appearance:: |
Yellowish Crystal |
Molecular Formula:: |
C5H3BrFN |
Molecular Weight:: |
175.99 |
EINECS NO:: |
629-269-8 |
MDL NO:: |
MFCD00234011 |
CAS No:: |
41404-58-4 |
Appearance:: |
Yellowish Crystal |
Molecular Formula:: |
C5H3BrFN |
Molecular Weight:: |
175.99 |
EINECS NO:: |
629-269-8 |
MDL NO:: |
MFCD00234011 |
Product Description:
Product Name:2-bromo-5-fluoropyridine CAS 41404-58-4
Synonyms:
2-bromo-5-fluoro pyridine;
3-fluoro-6-bromopyridine;
Chemical & Physical Properties
Appearance:Yellowish crystal
Assay: 99%+
Boiling point: 80-83℃/44 mmHg
Melting point:30-31℃
Flash point:100℃
Density:1.707±0.06g/cm3
Pka:-1.63±0.10
Refractive index:1.5396
Application
Bromo-5-fluoropyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.
2-Bromo-5-fluoropyridine can be used in the synthesis of the following:
(1)5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
(2)5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid
It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.
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