Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 77359-11-6
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Bag,Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS No:: |
77359-11-6 |
Appearance:: |
White To Almost White Powder |
Molecular Formula:: |
C10H9NO6 |
Molecular Weight:: |
239.18 |
EINECS NO:: |
N/A |
MDL NO:: |
MFCD00191556 |
CAS No:: |
77359-11-6 |
Appearance:: |
White To Almost White Powder |
Molecular Formula:: |
C10H9NO6 |
Molecular Weight:: |
239.18 |
EINECS NO:: |
N/A |
MDL NO:: |
MFCD00191556 |
Product Description:
Product Name:4-Nitrobenzyl hydrogen malonate CAS 77359-11-6
Synonyms:
Malonic acid mono-4-nitrobenzyl ester;
Malonicacidmononitrobenzylester;
Chemical & Physical Properties
Appearance:White to Almost white powder
Assay: 99%+
Melting point:109℃
Boiling point::455.8±30.0℃
Density:1.447±0.06g/cm3
Solubility:soluble in Methanol
Pka:2.49±0.32
Application
4-Nitrobenzyl hydrogen malonate is a reagent used in the synthesis of (±)-thienamycin, a β-Lactam antibiotics. Also, it is useful for chiral key intermediate of carbapenem syntheses.
Preparation of mono-4-nitrobenzyl malonate:
In a flame-dried 150 mL pressure tube under argon, add 5.00 g (34.7 mmol) of Meldrum's acid and 40 mL of anhydrous MeCN.
Add 5.58 g (36.4 mmol) of p-nitrobenzyl alcohol to the resulting solution.
Cap the tube tightly and reflux the reaction overnight.
Concentrate the reaction mixture under reduced pressure.
Purify the residue using column chromatography with a 55/45 hexane/EtOAc mixture.
The resulting product is mono-4-nitrobenzyl malonate with a yield of 87%.
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