2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile CAS 82671-02-1

Product Description:

Product Name:2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile CAS 82671-02-1

Synonyms:

Cyano-2,6-dichloro-5-fluoropyridine, 2,6-Dichloro-5-fluoropyridine-3-carbonitrile;

3-Pyridinecarbonitrile,2,6-dichloro-5-fluoro-;

Chemical & Physical Properties

Appearance:Grayish white to yellowish brown crystalline solids

Assay: 99%+

Melting point:89-91℃

Boiling point:267.8±35.0℃

Flash point:115.8℃

Density:1.6175g/cm³

Pka:-6.91±0.1

Application

It is the intermediate of enoxacin.

Enoxacin is a broad-spectrum quinolone antibiotic developed by Daihon Pharmaceutical Co., LTD., which was first approved for marketing in Japan in 1986. By acting on the A subunit of bacterial DNA helicase, it inhibits DNA synthesis and replication, resulting in bacterial death. This product has a broad spectrum of antibacterial action, especially against aerobic gram-negative bacilli with high antibacterial activity, and has good antibacterial action against the following bacteria in vitro: most bacteria of the Enterobacteriaceae, including citrobacter, Clostridium, Enterobacter aerogenes, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. It also has antibacterial activity against multi-drug resistant bacteria. The penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella have high antibacterial activity. It has antibacterial effect on most strains of Pseudomonas such as Pseudomonas aeruginosa. This product has antibacterial activity against methicillin-sensitive staphylococcus, and only moderate antibacterial activity against streptococcus pneumoniae, hemolytic streptococcus and Enterococcus faecalis. It has good antimicrobial activity against Chlamydia trachomatis, mycoplasma and Legionella, and also has antibacterial activity against tuberculosis bacillus and atypical Mycobacterium. Poor antibacterial activity against anaerobic bacteria. It is used to treat urinary, reproductive system, respiratory tract, digestive system, skin soft tissue, ear, nose, throat and eye infection caused by various bacteria and viruses.

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