Vismodegib CAS 879085-55-9 API Active Pharmaceutical Ingredient

Product Description:

Product Name:Vismodegib CAS 879085-55-9

Synonyms:

2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide;BROMO-1-NAPHTA

BenzaMide, 2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(Methylsulfonyl)-;

VisModegib (GDC-0449);

Chemical & Physical Properties

Appearance:White to Off-White Solid

Assay: 99%+

Boiling point:561.6±50.0 ℃

Melting Point:179-181℃

Molecular Weight:421.3

Density:1.440

Pka:10.72±0.70

Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Application:

Vimodej targets SMO protein and inhibits Gli activation, thereby inhibiting downstream gene transcription and expression.For the treatment of locally progressive or metastatic basal cell carcinoma in adults who have recurred after surgery or are not well treated with surgery or radiotherapy; One of the most common skin cancers is basal cell carcinoma (BCC), which originates in the surface layer of the skin and does not cause pain to patients. The risk was greatest for skin diseases that were regularly exposed to the sun or ultraviolet light. The development and listing of Vimedji has brought good news to patients with BCC, and its clinical role is important and the target market is huge, and it has to grow into a "giant bomb" class (> $1 billion) drug in the future.

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