Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 871700-17-3
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Bag,Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS No:: |
871700-17-3 |
Appearance:: |
White Solid |
Molecular Formula:: |
C26H23FIN5O4 |
Molecular Weight:: |
615.39 |
EINECS NO:: |
629-899-3 |
MDL NO.:: |
MFCD17215075 |
CAS No:: |
871700-17-3 |
Appearance:: |
White Solid |
Molecular Formula:: |
C26H23FIN5O4 |
Molecular Weight:: |
615.39 |
EINECS NO:: |
629-899-3 |
MDL NO.:: |
MFCD17215075 |
Product Description:
Product Name:Trametinib CAS 871700-17-3
Synonyms:
Trametinib free base;
N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide;
Trametinib Impurity;
Chemical & Physical Properties
Appearance:White solid
Assay: 99%+
Melting point:300-301℃
Density:1.743g/cm3
Solublility:Soluble in DMSO (up to 20 mg/ml)
Pka:14.76±0.70
Application:Trametinib is a MEK1/2 inhibitor, which affects MAPK pathway and inhibits cell proliferation mainly through its effect on MEK protein. MEK is a downstream signal transduction protein of RAS and RAF, so trametinib may also be effective against cancer species with RAS or RAF mutations. Such as non-small cell lung cancer, melanoma, thyroid cancer.
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