Mobocertinib Succinate CAS 2389149-74-8

Product Description:

Product Name: Mobocertinib succinate CAS 2389149-74-8

Synonyms:

TAK-788 Succinic acid;

obocertinib Succinate ;

Propan-2-yl 2-(5-(acryloylamino)-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyanilino)-4-(1-methyl-1H-indol-3yl)pyrimidine-5-carboxylate succinate

Chemical & Physical Properties

Appearance: white to off-white powder

Assay: NLT99%

solubility:DMSO : 25 mg/mL (35.52 mM; Need ultrasonic)

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 293499.9001

Uses:

Mobocertinib succinate is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity.Mobocertinib, also known as TAK-788 and AP32788, is an investigational TKI with potent, selective preclinical activity against activating EGFR and HER2 mutations, including exon 20 insertions. TAK-788 exhibits antitumor activity in pts with EGFR exon 20 insertions with an AE profile consistent with other EGFR TKIs.

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