Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 2370013-49-1
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Bag,Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS No:: |
2370013-49-1 |
Appearance:: |
Solid |
Molecular Formula:: |
C29H35ClFN7O3 |
Molecular Weight:: |
584.08 |
EINECS NO:: |
N/A |
MDL NO:: |
N/A |
CAS No:: |
2370013-49-1 |
Appearance:: |
Solid |
Molecular Formula:: |
C29H35ClFN7O3 |
Molecular Weight:: |
584.08 |
EINECS NO:: |
N/A |
MDL NO:: |
N/A |
Product Description:
DZD9008 CAS 2370013-49-1
Synonyms:
2-Propenamide,N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyph-enyl]-;(S)-Sunvozertinib
Chemical & Physical Properties
Appearance:solid
Assay: NLT99%
XLogP3-AA:5
Hydrogen Bond Donor Count :4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Solubility:DMSO:50 mg/mL (85.60 mM; Need ultrasonic)
Exact Mass:583.2473939 g/mol
Complexity:885
Defined Atom Stereocenter Count:1
Undefined Atom Stereocenter Count:0
Uses :
(S)-Sunvozertinib shows proliferation inhibition of Ba/F3 EGFR NPH ins (GI50=139.7 nM), Ba/F3 FGFR ASV ins (155.7 nM), NCI-HI975 EGFRL858R/T790M (24.4), Her2 YVMA ins (827 nM) and WT EGFR (84.8 nM).
(S)-Sunvozertinib shows proliferation inhibition of BTK WT cells (OCI-LY-10, TMD-8, Ri-1and DB, with GI50 ranging from 13.7-48 nM).
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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