Brefeldin A CAS 20350-15-6

Product Description:

Product Name: Brefeldin A CAS NO: 20350-15-6

Synonyms:

(1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-Methyl-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one;

Ascotoxin, Cyanein, DecuMbin;

Brefeldin A, FroM EupenicilliuM brefeldianuM;

Chemical & Physical Properties:

Appearance: White solid

Assay :≥99.0%

Density: 1.108 g/cm3

Boiling Point: 492.7℃ at 760 mmHg

Melting Point: 200-205℃

Flash Point: 87℃

Refractive Index: 1.513

Storage Condition: 2-8℃

Vapor Pressure: 0mmHg at 25℃

Water Solubility: Soluble in dimethylsulfoxide, dichloromethane and ethanol. Slightly soluble in water.

Safety Information:

RTECS: GY8410000

Safety Statements: S24/25; S45; S36; S26

WGK Germany: 3

RIDADR: UN 2811 6

Risk Statement: R25

Hazard Codes: Xn; T

Brefeldin A is a lactone antibiotic produced by fungal organisms such as Eupenicillium brefeldianum. Brefeldin A inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus indirectly by preventing formation of COPI-mediated transport vesicles. Brefeldin A was initially isolated as an anti-viral antibiotic but is now primarily used in biological research to study protein transport. Brefeldin A is a potent inhibitor of cell growth first described in 1958, then independently rediscovered by several groups as a potent active in a broad range of bioassays. Brefeldin has antiviral, antibiotic, antifungal, antitumour and herbicidal activity. Early studies on the mode of action of brefeldin identified inhibition of protein and nucleic acid synthesis by disruption of the Golgi apparatus. The precise molecular target is a subset of Sec7-type GTP exchange factors (GEFs) that activate a small GTPase, Arf1p, an integral component of protein trafficking and signalling.

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