Ansamitocin P-0 CAS 57103-68-1

Product Description:

Product Name: Ansamitocin P-0 CAS NO: 57103-68-1

Synonyms:

O3-de-(N-acetyl-N-methyl-L-alanyl)-maytansine;

(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84,12c-dihydroxy-15,7r-dimetho-xy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione;

Maytansinol (7);

Chemical & Physical Properties:

Appearance: Off-white to orange solid

Assay :≥99.0%

Density: 1.34g/cm3

Boiling Point: 835.8℃ at 760mmHg

Flash Point: 459.3℃

Refractive Index: 1.607

Vapour Pressure: 0.0±3.2 mmHg at 25℃

Maytansinol is used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity. Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.

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