MonoMethyl Auristatin E(MMAE) CAS 474645-27-7

Product Description:

Product Name: MonoMethyl auristatin E(MMAE) CAS NO: 474645-27-7

Synonyms:

HM-297C-22;

MonoMethyl auristatin E;MMAE;

N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-metho-xy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-metho-xy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide Monomethyl;

Chemical & Physical Properties:

Appearance: Solid powder

Assay :≥99.0%

Boiling Point: 873.5±65.0 °C(Predicted)

Density: 1.088±0.06 g/cm3(Predicted)

Pka: 13.66±0.20(Predicted)

Vapour Pressure: 0.0±0.3 mmHg at 25°C

Index of Refraction: 1.519

MMAE is an effective and synthetic cytotoxic analog of Dolastatin 10 which is a potent antimitotic polypeptide isolated from a marine animal.

Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization. Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.