3-Aminobenzamide CAS 3544-24-9

Product Description:

Product Name: 3-Aminobenzamide CAS NO: 3544-24-9

Synonyms:

meta-aminobenzoylamine;

Benzamide,m-amino;

5-amino-benzamide;

Chemical & Physical Properties:

Appearance: White to off-white powder

Assay :≥99.0%

Density: 1.233 g/cm3

Boiling Point: 329.6℃ at 760 mmHg

Melting Point: 111-115℃

Flash Point: 153.2℃

Refractive Index: 1.632

Storage Condition: Store under inert gas

Water Solubility: Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).

Sensitive: Light Sensitive

Safety Information:

RTECS: CU8992000

Safety Statements: S26-S37/39

HS Code: 2924299090

WGK Germany: 3

Risk Statements: R36/37/38

Hazard Code: Xi

Signal Word: Warning

Symbol: GHS07

Caution Statement: P280; P301 + P312 + P330; P304 + P340 + P312; P305 + P351 + P338; P337 + P313

Hazard Declaration: H302; H315; H319; H335

3-Aminobenzamide is a benzamide. It is an off-white powder and has the chemical formula C7H8N2O. The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

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