Canrenone CAS 976-71-6

Product Description:

Product Name: Canrenone CAS NO: 976-71-6

Synonyms:

phanurane;

Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, (17α)-;

pregna-4,6-diene-21-carboxylicacid,17-hydroxy-3-oxo-,gamma-lactone,(17-alph;

Chemical & Physical Properties:

Appearance: White to beige powder

Assay :≥99.0%

Density: 1.19g/cm3

Boiling Point: 541.1℃ at 760mmHg

Melting Point: 158-160℃

Flash Point: 237.6℃

Refractive Index: 1.581

Storage Condition: Store at RT

Safety Information:

Hazard Codes: Xn,N

Risk Statements: R40-51/53

Safety Statements: S36/37-61

RIDADR: UN 3077 9 / PGIII

WGK Germany: 3

HS Code: 29329990

Canrenone (INN, USAN) (brand names Contaren, Luvion, Phanurane, Spiroletan), also known as aldadiene, is a steroidal antimineralocorticoid and weak antiandrogen and progestogen of the spirolactone group related to spironolactone which is or has been used as a diuretic in Europe, including in Italy and Belgium.

Carenone is an active metabolite of spironolactone, canrenoic acid, and potassium canrenoate, and is believed to be partially or largely responsible for their effects (depending on the drug in question).

Canrenone is more potent as an antimineralocorticoid relative to spironolactone, but is considerably less potent and effective as an antiandrogen. Similarly to spironolactone, canrenone inhibits steroidogenic enzymes such as 11β-hydroxylase, cholesterol side-chain cleavage enzyme, 17α-hydroxylase, and 21-hydroxylase, but once again, is comparatively less potent in doing so.

Canrenone has been found to be effective in the treatment of hirsutism in women.

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