Prednisolone CAS 50-24-8

Product Description:

Product Name: Prednisolone CAS NO: 50-24-8

Synonyms:

DEHYDROHYDROCORTISONE;

HYDRODELTALONE;

METACORT AND RALONE;

Chemical & Physical Properties:

Appearance:White to white powder

Assay :≥99.0%

Density: 1.3±0.1 g/cm3

Boiling Point: 570.6±50.0℃ at 760 mmHg

Melting Point: 240℃ (dec.)(lit.)

Flash Point: 313.0±26.6℃

Vapour Pressure: 0.0±3.6 mmHg at 25℃

Index of Refraction: 1.612

Storage Condition: -20℃ Freezer

Safety Information:

HS Code: 2937229000

Prednisolone is a glucocorticoid with the general properties of the corticosteroids.Target: Glucocorticoid ReceptorPrednisolone is a glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Prednisolone, 5 or 50 mg/kg, was administered intravenously to adrenalectomized rats. Total plasma, free plasma, CBG-free plasma, and liver prednisolone concentrations were measured simultaneously with free hepatic cytosolic glucocorticoid receptor concentrations and tyrosine aminotransferase (TAT) activity of the liver as a function of time. prednisolone pharmacokinetics were dose-dependent, parameters describing receptor kinetics and TAT activity were constant at each prednisolone dose. The major determinants of receptor-mediated glucocorticoid activity are confirmed to be the availability of the receptor, drug-receptor dissociation rate, and corticosteroid persistence in the biophase.

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