Ciclopirox CAS 29342-05-0 EINECS NO 249-577-2

Product Description:

Product Name: Ciclopirox CAS NO: 29342-05-0

Synonyms:

1-Hydroxy-4-methyl-6-cyclohexyl-2-pyridone;

6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one;

6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone;

Chemical & Physical Properties:

Appearance: White or light-yellow powder

Assay :≥99.0%

Density: 1.193 g/cm3

Boiling Point: 350℃ at 760 mmHg

Melting Point: 144℃

Flash Point: 165.5℃

Refractive Index: 1.582

Storage Condition: Store in original container in a cool dark place.

Vapor Pressure: 2.71E-06mmHg at 25℃

Safety Information:

RTECS: QU5900000

Hazard Class: 8

Safety Statements: S23; S26; S36; S45

HS Code: 2933790090

Packing Group: II

WGK Germany: 1

RIDADR: UN 3264 8/PG 3

Risk Statements: R8; R35; R34; R20

Hazard Codes: C; O

Ciclopirox olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. It is sold under many brand names worldwide. Ciclopirox (Penlac) is a synthetic antifungal agent.Target: AntifungalCiclopirox is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. The mechanism of action of ciclopirox is poorly understood. However, loss of function of certain catalase and peroxidase enzymes has been implicated as the mechanism of action, as well as various other components of cellular metabolism. In a study conducted to further elucidate ciclopirox's mechanism, several Saccharomyces cerevisiae mutants were screened and tested. Results from interpretation of the effects of both the drug treatment and mutation suggested that ciclopirox may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport. It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase. It is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur. Initial results show similar efficacy to ketoconazole with a relative increase in subjective symptom relief due to its inherent anti-inflammatory properties.

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