(S)-2-methylproline Hydrochloride CAS 1508261-86-6

Product Description:

Product Name: (S)-2-methylproline hydrochloride CAS 1508261-86-6

Synonyms:

(S)-2-methylpyrrolidine-2-carboxylic acid Hydrochloride;

2-Methyl-L-proline hydrochloride;

Chemical & Physical Properties:

Appearance: Pale Beige to Pale Brown Solid

Assay :≥99.0%

2-Methyl-L-proline hydrochloride is an important intermediate of the anti-cancer drug Veliparib (ABT-888) and an effective inhibitor of poly (ADP ribose polymerase) -1 and PARP-2. At present, the drug is undergoing clinical trials in the United States for the treatment of different tumors, including two Phase III clinical trials on breast cancer just launched last year. The first item is the safety and effectiveness of the combination of Veliparib and chemotherapy drug carboplatin (CBP) for early, triple negative breast cancer. This clinical trial is divided into three groups. Veliparib+carboplatin or placebo+carboplatin will be compared with standard neoadjuvant chemotherapy (NCTO2032277). The second item is the combination of Veliparib and chemotherapy in the treatment of breast cancer. This study will compare the effect of Veliparib combined with chemotherapy drugs paclitaxel and carboplatin and chemotherapy alone on HER2 negative and BRCA1/2 positive breast cancer patients (NCT02163694).

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.