10-Hydroxycamptothecin CAS 19685-09-7

Product Description:

Product Name: 10-Hydroxycamptothecin CAS NO: 19685-09-7

Synonyms:

Camptothecin,hydroxy;

Hydroxycamptothecine;

10-OH-camptothecin;

Chemical & Physical Properties:

Appearance: Yellow Solid

Assay :≥99.0%

Density: 1.60

Melting Point: 265-270℃

Boiling Point: 820.7±65.0℃(Predicted)

Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20℃

Safety Information:

HS Code: 2934999090

Safety Statements: S24/25

A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. (S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.IC50 value:Target:In vitro: In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics, and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections [1].In vivo: The in vivo study with H22 tumor-bearing mice and intravenous injection of the drug showed that in contrast to the 10-hydroxycamptothecin injections, the 10-hydroxycamptothecin nanosuspensions exhibited significantly enhanced biodistribution, particularly in the lung (393.40-fold AUC0–24 h, liver (192.35-fold AUC0–24 h, spleen (141.67-fold AUC0–24 h and tumor (64.21-fold AUC0–24 h. The 10-hydroxycamptothecin nanosuspensions also showed improved antitumor therapeutic efficacy over the injections (89.83% vs. 30.56%) .

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