Aprocitentan CAS 1103522-45-7

Product Description:

Product Name: Aprocitentan CAS 1103522-45-7

Synonyms:

N-Despropyl-macitentan;

5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine;

Chemical & Physical Properties:

Appearance: white to off-white powder

Assay: ≥ 99.0%

Melting Point:139-141℃

Density: 1.841g/cm3

Solubility: soluble in chloroform (slightly heated), methanol (slightly heated)

Uses

N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH).

ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ethe r, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.

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