Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1903768-17-1
Payment & Shipping Terms
Minimum Order Quantity: negotiation
Price: negotiation
Packaging Details: bag;Drum
Delivery Time: 7-15 days
Payment Terms: T/T, D/A, L/C, Western Union
Supply Ability: KG
CAS NO:: |
1903768-17-1 |
Appearance:: |
White To Off-white Powder |
Molecular Formula:: |
C26H23BrFN7O3 |
Molecular Weight:: |
580.41 |
EINECS NO:: |
968-712-2 |
MDL NO:: |
MFCD32669786 |
CAS NO:: |
1903768-17-1 |
Appearance:: |
White To Off-white Powder |
Molecular Formula:: |
C26H23BrFN7O3 |
Molecular Weight:: |
580.41 |
EINECS NO:: |
968-712-2 |
MDL NO:: |
MFCD32669786 |
Product Description:
Product Name: Danicopan CAS 1903768-17-1
Synonyms:
Danicopan free base;
(2S,4R)-1-(2-(3-Acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide;
Chemical & Physical Properties:
Appearance: white to off-white powder
Assay: ≥ 98.0%
Boiling Point: 847.1℃
Density: 1.61g/cm3
Solubility: DMSO:175.0(Max Conc. mg/mL);301.51(Max Conc. mM)
Uses
Danicapan (ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040) is an effective and selective oral inhibitor of factor D, with a Kd value of 0.54 nM for human factor D. Danicapan can inhibit the activity of alternative pathway of complement (APC) and has the potential to block the complement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
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