Elinzanetant CAS 929046-33-3

Product Description:

Product Name: elinzanetant CAS 929046-33-3

Synonyms:

N-[6-[(7S,9aS)-7-(hydroxymethyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide;

Chemical & Physical Properties:

Appearance: white to Light yellow powder

Assay: ≥ 99.0%

Boiling point: 672.1±55.0 ℃ at 760 mmHg

Flash Point: 360.3±31.5℃

Density: 1.4 g/cm3

Solubility: Soluble in DMSO 100mg/ml

Uses

Elinzanetant is an bioavailable neurokinin/tachykinin 1 receptor (NK1-receptor; NK1R; NK-1R) and NK3 receptor (NK-3R; NK3R) antagonist, that may be used to treat vasomotor symptoms in menopausal woman. Upon oral administration, elinzanetant targets, competitively binds to and blocks the activity of the NK1R and NK3R in the central nervous system (CNS), thereby inhibiting the binding of the endogenous ligands and neuropeptides substance P (SP; neurokinin-1; NK1) and neurokinin B (NKB). This inhibits NK1R/NK3R-mediated signal transduction and may prevent certain menopausal symptoms such as hot flashes. Neurokinin-mediated signaling may increase during hormone deficiency and may cause hot flashes..

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