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Home > products > API Active Pharmaceutical Ingredient > Azlocillin Sodium CAS 37091-65-9

Azlocillin Sodium CAS 37091-65-9

Product Details

Place of Origin: China

Brand Name: Sunshine

Certification: ISO,COA

Model Number: 37091-65-9

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Packaging Details: Bag,Drum

Delivery Time: 7-15 days

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Highlight:
CAS NO::
37091-65-9
Appearance::
White To Almost White Powder
Molecular Formula::
C20H22N5NaO6S
Molecular Weight::
483.47300
EINECS NO::
253-347-7
MDL NO::
MFCD00864967
CAS NO::
37091-65-9
Appearance::
White To Almost White Powder
Molecular Formula::
C20H22N5NaO6S
Molecular Weight::
483.47300
EINECS NO::
253-347-7
MDL NO::
MFCD00864967
Azlocillin Sodium CAS 37091-65-9

Product Description:

Product Name: Azlocillin sodium CAS NO: 37091-65-9

 

 

Synonyms:

D-alpha-([Imidazolidin-2-on-1-yl]carbonylamino)benzylpenicillin;

Sodium[2S-[2a,5a,6b(S*)]]-3,3-dimethyl-7-oxo-6-[[[[(2-oxoimidazolidin-1-yl)carbonyl]amino]phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;

Azlocillin sodium salt;

 

 

Chemical & Physical Properties:

Appearance:White to almost white powder

Assay :≥99.0%

Storage temp.: Inert atmosphere,2-8℃

Solubility: H2O: soluble50mg/mL

Water Solubility: Freely soluble in water

 

 

Safety Information:

Safety Statement: S36

HS Code: 2942000000

Risk Statements: R42/43

Hazard Code: Xn

 

 

Azlocillin is an acylampicillin with a broad spectrum against bacteria.Target: AntibacterialAzlocillin (12.5 μg/mL) inhibits over 75% of the isolates of Pseudomonas aeruginosa. Azlocillin (12.5 μg/mL) is also active against indole-negative and -positive Proteus spp., inhibiting 98 and 71%, respectively. Azlocillin is more active than mezlocillin, ticarcillin, and carbenicillin and as active as BLP-1654 against isolates of P. aeruginosa. The acyl side chains of Azlocillin have an ureido-(urea) structurehence the name "ureidopenicillins" or, more specifically, "acylureidopenicillins." In vitro studies against P. aeruginosa demonstrates that piperacillin has activity that is twice that of azlocillin, 4 times that of mezlocillin and ticarcillin, and about 8 times that of carbenicillin. Azlocillin produces elongated bacterial forms with delayed or no lysis in morphologic studies.Azlocillin has MICs of 12.5 μg/mL on Pseudomonas aeruginosa. Azlocillin (3.125 μg/mL) results in a reduction in the rate of growth but no bactericidal phase on Pseudomonas aeruginosa. Azlocillin decreases an initial lag phase with increasing drug concentration. At the lower concentration of tobramycin (0.5 μg/ml), the combinations with both the high and the low concentrations of Azlocillin are more effective than the individual components on Pseudomonas aeruginosa. Isolates with derepression of AmpC enzyme are one to two doubling dilutions more resistant to azlocillin than are those in which increased efflux or impermeability is inferred. Those with secondary β-lactamases are mostly (12/14 cases) susceptible to ceftazidime at 4 mg/L, but are amongst the most resistant to Azlocillin (MIC ≥128 mg/L in 10/14 cases) .

 

 

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