Domperidone CAS 57808-66-9

Product Description:

Product Name: Domperidone CAS NO: 57808-66-9

Synonyms:

midazol-1-yl)propyl)-4-piperidinyl)-;

5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one;

DoMperidone Sustained Release Pellets;

Chemical & Physical Properties:

Appearance: White powder

Assay :≥99.0%

Density: 1.341 g/cm3

Melting Point: 242.5℃

Stability: Stable. Incompatible with strong oxidizing agents.

Storage Condition: Keep tightly closed.

Safety Information:

RTECS: DE2275900

Safety Statements: S26-S36

HS Code: 2933990090

WGK Germany: 3

Risk Statements: R62; R63

Hazard Code: Xn

A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. Domperidone is a dopamine blocker and an antidopaminergic reagent.Target: Dopamine ReceptorDomperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets. Domperidone is a dopamine D(2) receptor antagonist, which has been used as antiemetic agent in human beings. The percentage recovery of domperidone from wastewater was 95.0%. Celiprolol was used as the internal standard to access the percentage extraction of domperidone from wastewater. Domperidone, a dopamine antagonist that does not easily cross the blood-brain barrier, is considered the gold standard for treating gastrointestinal symptoms in patients with Parkinson's disease (PD) because the risk of developing extrapyramidal adverse effects is considered minimal.

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