Estriol CAS 50-27-1

Product Description:

Product Name: Estriol CAS NO: 50-27-1

Synonyms:

ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL;

ESTRA-1,3,5(10)-TRIENE-3,16ALPHA,17BETA-TRIOL;TRIDESTRIN;

ESTRIOL(P);

Chemical & Physical Properties:

Appearance: White crystalline powder

Assay :≥99.0%

Density: 1.255g/cm3

Boiling Point: 469℃ at 760 mmHg

Melting Point: 281-282℃

Flash Point: 220.8℃

Refractive Index: 1.624

Storage Condition: -20℃ Freezer

Safety Information:

RTECS: KG8225000

Safety Statements: S53-22-36/37/39-45-36/37

WGK Germany: 3

Risk Statement: R60

Hazard Codes: T,F

Estriol is an antagonist of the G-protein coupled estro-gen receptor in estro-gen receptor-negative breast cancer cells.Target: Estro-gen Receptor/ERRA recent study shows that estro-gen (estrone, estradiol, and estriol) inhibits Alzheimer's disease-associated low-order Aβ oligomer formation, and among them, estriol shows the strongest in vitro activity. In mPTEN+/- mice, estriol treatments resulted in a 187.54% gain in the relative ratio of uterine wet weight to body weight; estriol also increases the ratio to 176.88% in wild-type mice. Estriol treatment (20 mg/kg ip), in vivo, sensitizes Kupffer cells to LPS via mechanisms dependent on an increase in CD14 by elevated portal blood endotoxin caused by increased gut permeability in rats; while one-half of the rats given estriol intraperitoneally 24 hours before an injection of a sublethal dose of LPS (5 mg/kg) died within 24 hours.

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