Estronel CAS 53-16-7

Product Description:

Product Name: Estronel CAS NO: 53-16-7

Synonyms:

Estra-1,3,5(10)-trien-17-one, 3-hydroxy-;

3-Hydroxy-1,3,5(10)-estratrien-17-one;

1,3,5(10)-Estratrien-3-ol-17-one;

Chemical & Physical Properties:

Appearance: White crystalline powder

Assay :≥99.0%

Density: 1.164 g/cm3

Boiling Point: 445.2℃ at 760 mmHg

Melting Point: 258-261℃

Flash Point: 189.7℃

Refractive Index: 165 ° (C=1, Dioxane)

Water Solubility: 0.03 g/L

Stability: Stable under normal temperatures and pressures.

Storage Condition: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

Safety Information:

RTECS: KG8575000

Safety Statements: S53-S45

HS Code: 2937290090

WGK Germany: 3

Packing Group: I; II; III

Risk Statements: R45; R60; R61

Hazard Code: T

Hazard Declaration: H225; H301 + H311 + H331; H370

Symbol: GHS02, GHS06, GHS08

Caution Statement: P210; P260; P280; P301 + P310 + P330; P302 + P352 + P312; P370 + P378

Signal Word: Danger

Estrone (E1, and also oestrone) is an estro-genic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is an odorless, solid crystalline powder, white in color with a melting point of 254.5°C and a specific gravity of 1.23. Estrone is one of several natural estro-gens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy.

Estrone is known to be a carcinogen for human females as well as a cause of breast tenderness or pain, nausea, headache, hypertension, and leg cramps in the context of non-endogenous exposure. In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile dysfunction. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estro-gen in postmenopausal women.

Estrone was discovered and isolated by German chemist Adolf Butenandt.

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