2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic Acid CAS 594839-88-0

Product Description:

Product Name: 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid CAS NO: 594839-88-0

Synonyms:

8FG9H9D31J;

TAFAMIDIS;

UNII-8FG9H9D31J;

Chemical & Physical Properties:

Appearance: Solid powder

Assay :≥99.0%

Density: 1.53

Boiling Point: 486.7±40.0℃(Predicted)

Flash Point: 248.1±27.3℃

Vapour Pressure: 0.0±1.3 mmHg at 25℃

Index of Refraction: 1.677

Tafamidis(Fx1006A) is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.Target: OthersTafamidis is a drug for the amelioration of transthyretin-related hereditary amyloidosis.Tafamidis functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein. Tafamidis binds selectively and with negative cooperativity (K(d)s ~2 nM and ~200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. Patient-derived amyloidogenic variants of TTR, including kinetically and thermodynamically less stable mutants, are also stabilized by tafamidis binding. The crystal structure of tafamidis-bound TTR suggests that binding stabilizes the weaker dimer-dimer interface against dissociation, the rate-limiting step of amyloidogenesis.

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