Aliskiren CAS 173334-57-1

Product Description:

Product Name: Aliskiren CAS NO: 173334-57-1

Synonyms:

(aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-metho-xy-3-(3-metho-xypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide;

Rasilez;

(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-metho-xy-3-(3-metho-xypropoxy)benzyl]-8-methylnonanamide;

Chemical & Physical Properties:

Appearance: Powder or liquid

Assay :≥99.0%

Density: 1.067 g/cm3

Boiling Point: 748.4℃ at 760 mmHg

Flash Point: 406.4℃

Vapor Pressure: 1.12E-24mmHg at 25℃

Index of Refraction: 1.514

Aliskiren (trade names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors. Its is used for essential (primary) hypertension. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit.

In December 2011, Novartis halted a trial of the drug after discovering increased nonfatal stroke, kidney complications, high blood potassium, and low blood pressure in people with diabetes and kidney problems.

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