Bicalutamide CAS 90357-06-5

Product Description:

Product Name: Bicalutamide CAS NO: 90357-06-5

Synonyms:

N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide;

Cosudex;

BicalutaMide API;

Chemical & Physical Properties:

Appearance: Off-white crystalline solid

Assay :≥99.0%

Density: 1.52 g/cm3

Boiling Point: 650.3℃ at 760 mmHg

Melting Point: 191-193℃

Flash Point: 347.1℃

Refractive Index: 1.577

Storage Condition: Store in original container in a cool dark place.

Safety Information:

Hazard Class: 9

Safety Statements: S26; S36

HS Code: 2929909090

Packing Group: III

RIDADR: 3077

Risk Statements: R36/37/38

Hazard Code: Xi

Non-steroi-dal peripherally active antiandro-gen. Used as an antiandro-gen, antineoplastic (hormonal). Bicalutamide was launched in the United Kingdom, its first worldwide market, for the treatment of advanced prostate cancer in combination with an LHRH analog or surgical castration. A non-steroi-dal, peripherally selective antiandro-gen, bicalutamide inhibits the action of dihydrotestostero-ne and testostero-ne at target sites by competitive binding to the cytosolic andro-gen receptor. It was reportedly well tolerated with no significant cardiovascular and metabolic side effects due to the benefit of lacking any steroi-d activity. The efficacy of bicalutamide as a monotherapy has been demonstrated clinically. Promising response rates were also reported in treating colorectal, breast, pancreas and non-small cell lung cancers.

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