MDL NO MFCD00017373 Aloe Emodin CAS 481-72-1

Product Description:

Product Name: Aloe emodin CAS NO: 481-72-1

Synonyms:

1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone,3-Hydroxymethylchrysazine,Aloe-emodin;

3-Hydroxymethylchrysazin;

1H-Indazole-3-carboxylic acid,4,5,6,7-tetrahydro-, ethyl ester;

Chemical & Physical Properties:

Appearance: Orange Solid

Assay :≥99.0%

Density: 1.3280 (rough estimate)

Melting Point: 223-224℃

Storage Condition: 2-8℃

Flash Point: 311.9±26.6 °C

Vapour Pressure: 0.0±1.6 mmHg at 25℃

Index of Refraction: 1.746

Stability: Hygroscopic

Safety Information:

RTECS: CB6712200

Safety Statements: S26; S36

WGK Germany: 3

Risk Statements: R36/37/38

Hazard Code: Xi

Aloe emodin is a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antitumor activity.IC50 value:Target:in vitro: aloe-emodin treatment led to the dissociation of heat shock protein 90 (HSP90) and ER α and increased ER α ubiquitination. Protein fractionation results suggest that aloe-emodin tended to induce cytosolic ER α degradation. Aloe-emodin, a natural compound found in aloe, inhibited both proliferation and anchorage-independent growth of PC3 cells. Protein content analysis suggested that activation of the downstream substrates of mTORC2, Akt and PKCα, was inhibited by aloe-emodin treatment. Pull-down assay and in vitro kinase assay results indicated that aloe-emodin could bind with mTORC2 in cells and inhibit its kinase activity. Of three anthraquinone derivatives, aloe-emodin, with a lower cytotoxicity showed concentration-dependently reducing virus-induced cytopathic effect and inhibiting replication of influenza A in MDCK cells. Galectin-3 also inhibited influenza A virus replication. Proteomic analysis of treated cells indicated galectin-3 up-regulation as one anti-influenza A virus action by aloe-emodin. Since galectin-3 exhibited cytokine-like regulatory actions via JAK/STAT pathways, aloe-emodin also restored NS1-inhibited STAT1-mediated antiviral responses in transfected cells: e.g., STAT1 phosphorylation of interferon (IFN) stimulation response element (ISRE)-driven promoter, RNA-dependent protein kinase (PKR) and 2'5',-oligoadenylate synthetase (2'5',-OAS) expression. AE downregulated mRNA expression and promoter/gelatinolytic activity of Matrix Metalloproteinase (MMP)-2/9, as well as the RhoB expression at gene and protein level. AE suppressed the nuclear translocation and DNA binding of NF-κB.in vivo: Aloe-emodin also exhibited tumor suppression effects in vivo in an athymic nude mouse model.

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