(S)-(+)-Ibuprofen CAS 51146-56-6 EINECS NO 610-620-9

Product Description:

Product Name: (S)-(+)-Ibuprofen CAS NO: 51146-56-6

Synonyms:

(S)-(+)-4-Isobutyl-Alpha-Methylphenylacetic Acid;

(S)-2-(4-Isobutylphenyl)propanoic acid;

(S)-(+)-2-(4-Isobutylphenyl)propionic Acid;

Chemical & Physical Properties:

Appearance: Colourless, crystalline solid

Assay :≥99.0%

Density: 1.029 g/cm3

Boiling Point: 319.6℃ at 760 mmHg

Melting Point: 49-53℃

Flash Point: 113℃

Stability: Stable. Incompatible with strong oxidizing agents.

Storage Condition: Store at RT

Safety Information:

Safety Statements: S36/37-S45

HS Code: 2916399090

Risk Statements: R22; R63

Hazard Code: Xn

A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer. Dexibuprofen, the S-(+)-isomer of the widely used NSAID agent ibuprofen, was launched in Austria for the treatment of rheumatoid arthritis. While the racemic compound is commonly used clinically, the antiinflammatory activity is mediated via the S-isomer by inhibition of prostaglandin synthesis. It has also been demonstrated that the R-isomer is converted to the Santipode in vivo via a CoA thioester intermediate. Since CoA plays a pivotal role in intermediary metabolism and maintenance of the [acyl-CoA], generation of R-ibuprofen-CoA competitively inhibits many CoA-dependent reactions, which consequently produces perturbations of hepatocyte Intermediary metabolism and mitocondrial function. Pure S-ibuprofen usage, therefore, is preferred allowing a reduction in dosage level and an improved side effect profile.

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