Norandrostenedione CAS 734-32-7 Off-White Solid

Product Description:

Product Name: Norandrostenedione CAS NO: 734-32-7

Synonyms:

Estr-4-ene-3,17-dione;

Nor-4-Androstenedione;

19-nor-4-androstene-3,17-dione;

Chemical & Physical Properties:

Appearance: Off-White Solid

Assay :≥99.0%

Density: 1.13 g/cm3

Boiling Point: 433.4℃ at 760 mmHg

Melting Point: 169-172℃

Flash Point: 26.67℃

Refractive Index: 1.556

Storage Condition: Refrigerator

Safety Information:

Safety Statements: S16; S26; S36/37/39; S45

WGK Germany: 3

Risk Statement: R11

Hazard Codes: F; C

Bolandione, also known as 19-norandrostenedione (19-norandrost-4-en-3,17-dione), is a precursor of the anabolic steroi-d nandrolon-e. Until 2005, bolandione was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug. It is also banned from use in many sports, including the Olympic Games, under the World Anti-Doping Code. Bolandione is readily metabolized to nandrolon-e after oral administration, but its potency to transactivate the andro-gen receptor dependent reporter gene expression is 10 times lower as compared to dihydrotestosterone (DHT).

Scientific studies have shown that oral administration of bolandione is "a very ineffective strategy for stimulating skeletal muscle mass increases but may be associated with side effects".

In vivo experiments in castrated rats demonstrated that subcutaneous treatment with bolandione resulted only in a stimulation of the weight of the levator ani muscle, while the prostate and seminal vesicle weights remained completely unaffected. In contrast to its metabolite nandrolon-e, bolandione highly selectively stimulates the growth of the skeletal muscles but has only weak andro-genic properties.

In the early 2000s, contamination of androstenedione products with traces of bolandione caused false positives for doping tests for nandrolon-e because 19-norandrosterone is a metabolite of both nandrolon-e and bolandione. In a randomized controlled trial trace contamination of androstenedione with bolandione was sufficient for users of androstenedione to test positive for nandrolon-e. This detail became less relevant after bolandione and androstenedione were banned by major sporting bodies.

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