Cefoxitin CAS 35607-66-0 Effective Treatment

Product Description:

Product Name: Cefoxitin CAS NO: 35607-66-0

Synonyms:

(6r-cis)-ethyl)-7-metho-xy-8-oxo-7-((2-thienylacetyl)amino);

Cefoxitin{(6R-cis)-3-[(Carbamoyloxy)methyl]-7-metho-xy-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid};

Chemical & Physical Properties:

Appearance: White to off-white crystalline powder

Assay :≥99.0%

Density: 1.63 g/cm3

Boiling Point: 843.4℃ at 760 mmHg

Melting Point: 149 – 150℃

Refractive Index: 1.692

Water Solubility: Predicted solubility in water is less than 0.2mg/ml

Safety Information:

HS Code: 3003201300

Packing Group: III

RIDADR: UN 3077

Cefoxitin is a semi-synthetic antibiotic derived from Cephamycin C, possessing high resistance to β-lactamase inactivation. An antibacterial. Cefoxitin contains the same C-7 side chain as cephalothin and the same C-3 side chain as cefuroxime. The most novel chemical feature of cefoxitin is the possession of an α-oriented metho-xyl group in place of the normal H-atom at C-7. This increased steric bulk conveys very significant stability against β-lactamases. The inspiration for these functional groups was provided by the discovery of the naturally occurring antibiotic cephamycin C derived from fermentation of Streptomyces lactamdurans. Cephamycin C itself has not seen clinical use but, rather, has provided the structural clue that led to useful agents such as cefoxitin. Agents that contain this 7α metho-xy group are commonly referred to as cephamycins. Ingenious chemical transformations now enable synthetic introduction of such a metho-xy group into cephalosporins lacking this feature.

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