Valacyclovir Hydrochloride CAS 124832-27-5 for Herpes Treatment

Product Description:

Product Name: Valacyclovir hydrochloride CAS NO: 124832-27-5

Synonyms:

2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)metho-xy)ethyl ester monohydrochloride;

L-Valine 2-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-ylmetho-xy)ethyl Ester Hydrochloride Hydrate;

Valaciclovir;

Chemical & Physical Properties:

Appearance: White to off-white crystalline power

Assay :≥99.0%

Density: 1.55g/cm3

Boiling Point: 588.4℃ at 760 mmHg

Melting Point: 170-172℃

Flash Point: 309.7℃

Refractive Index: 1.673

Vapor Pressure: 7.95E-14mmHg at 25℃

Safety Information:

Safety Statements: S26; S36

HS Code: 2933990090

Risk Statements: R36/37/38

Hazard Codes: Xi,Xn

Hazard Declaration: H302

Signal Word: Warning

Symbol: GHS07

WGK Germany: 3

Valacyclovir hydrochloride is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. Target: HSVValacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. VACV uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64 +/- 0.06 mM and 23.34 +/- 0.36 nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, suggesting that hPEPT1 dominates the intestinal transport properties of VACV in vitro . For treatment of a first episode of genital herpes, a large comparative trial has shown that valacyclovir (1 g twice a day) is as effective as acyclovir (200 mg five times a day) when given for 10 days. For treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. A daily dose of 1 g of valacyclovir is as effective as 2 g daily. Valacyclovir can be administered once a day. The concentrations of acyclovir in serum and CSF were measured at steady state after 6 days of oral treatment with 1,000 mg of valacyclovir three times a day. EC50 values of PE and AC in 3T3 cells were 0.02 and 0.01 ug/ml, while values in BHK cells were 0.2 and 0.03 ug/ml. Treatment of infected immunosuppressed mice and FA and VA (b.i.d., 5.5 days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. Virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with VA.

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